7- Neuroradiological Endovascular Use A Complementary Histological Study

Two Landrace Large White swine underwent angiography by the femoral route.

In both cases, the superior left renal artery was embolized by injection of 2 ml of Glubran 2^®, diluted with Lipiodol 1:1 thereby excluding the superior left kidney poles from blood flow.

During the follow-up period, neither pig presented any clinical symptom correlated to the embolization procedure. Case 1 was sacrificed after 30 days and case 2 after 60 days. Macroscopic and microscopic analysis was performed in both animals.

Long-term follow-up of the two cases after endovascular injection of Glubran 2^® showed that the embolization procedure was well-tolerated by the swine in terms of clinical symptoms and histological findings. Arterial occlusion was stable and a reasonable quantity of scar tissue appeared between 30 and 60 days, surrounding the ischaemic tissue. This follow-up experimental study offers further evidence that Glubran 2^® is a safe embolizing material for human use as far as its chemical activity is concerned.