1- Treatment of fistula-in-ano with cyanoacrylate glue with and without prior seton placement in rats
Title: Treatment of fistula-in-ano with cyanoacrylate glue with and without prior seton placement in rats
Authors:
Tominaga Romero ,Carlos Henrique Marques dos Santos ,Pedro Carvalho Cassino ,Maçanori Odashiro ,Gisele Zocoller Seno ,Gabriela Flávia Aléssio Acta Cir. Bras. vol.31 no.6 São Paulo June 2016- https://doi.org/10.1590/S0102-865020160060000003
Abstract:
PURPOSE: To evaluate the efficacy of ethyl-cyanoacrylate in the treatment of fístula-in-ano in rats with and without prior seton placement.
METHODS: Thirty rats Wistar with fístula-in-ano produced surgically, distributed in three groups: group A (ethyl-cyanoacrylate) – treated by application of ethyl-cyanoacrylate into fístula tract; group B (seton + ethyl-cyanoacrylate) – seton placement followed by application of ethyl-cyanoacrylate into fístula tract, 30 days later; group C (control) – no treatment. After 60 days the animals were submited to euthanasia and the specimens were analyzed by pathologist. The results were analyzed by Chi-square test with significant value of p<0.05.
RESULTS: One animal of group B died. Were found tracts fully healed: 7, 5 and 2, in groups A, B and C, respectivelly. There was a statistically significant difference between groups A and C (p=0.02). When joined all animals treated with glue (A + B) compared to group C there was also statistically significant difference (p=0.02).
CONCLUSIONS: The use of ethyl-cyanoacrylate glue was effective in closing anal fistulae in rats. There was no advantage in the prior application of seton.
Key words: Anus Diseases; Therapeutic Uses; Cyanoacrylates; Rats.
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