16- Recent progress in surgical adhesives for biomedical applications
Title:
Recent progress in surgical adhesives for biomedical applications
Authors:
Kaikai Zheng a,b,*, Qinhao Gu c,1, Dong Zhou d, Muran Zhou e, Lei Zhang,Smart Materials in Medicine
Volume 3, 2022, Pages 41-65
Abstract:
Highlights
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This paper reviews the common methods of preparing bioadhesives.
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This paper reviews the mechanism of common bioadhesives on skin adhesion.
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This article reviews the materials used as bioadhesives and evaluates and prospects the current progress.
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This article reviews the clinical use of bioadhesives and evaluates their advantages and disadvantages.
Abstract
The increasing demands for the management of hemostasis and tissue sealing drive the development of novel bioadhesives, which can overcome the disadvantages of conventional sutures such as additional tissue damage, increased infection probability, and body fluid/air leakage. Bioadhesives can form a protective layer with seamless adhesion between the injured tissues, thereby quickly closing the wound and creating appropriate microenvironments for wound healing. In this review, the recent advancement in bioadhesives made of natural macromolecules (polysaccharides and proteins, etc.) and synthetic macromolecules (cyanoacrylate, polyethylene glycol, polyurethane, etc.) have been summarized. The gelation and adhesion mechanisms that determine the bioadhesive properties and sealing functions are highlighted, and the current clinical applications of bioadhesives are also discussed. Based on these findings, a brief outlook on the future of bioadhesive is explored.
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