25- Embolization-driven Occlusion of the Abdominal Aortic Aneurysmal Sac as the Basis of Prevention of Endoleaks in a New Swine Model
Title:
Embolization-driven Occlusion of the Abdominal Aortic Aneurysmal Sac as the Basis of Prevention of Endoleaks in a New Swine Model
Authors:
P.H.RollandV.VidalC.MekkaouiM.-F.BertrandO.LevrierJ.-M.Bartoli,European Journal of Vascular and Endovascular Surgery ,Volume 31, Issue 1, January 2006, Pages 28-35
https://doi.org/10.1016/j.ejvs.2005.07.018
Abstract:
Objectives
To assess the effect of a new polymer in embolization of endoleaks using an animal model.
Methods
A modified aortic stent-graft was placed in 20 pigs. Embolization was performed at the time of graft insertion with non-cytotoxic n-butyl-2-cyanoacrylate-metacryloxysulpholane and lipiodol (0.2:0.8ratio, 2 ml). Angiography, scanning electron microscopy and immuno-histochemistry were obtained at day 0, 1 week and 3 months.
Results
In control animals both type I and II endoleaks were demonstrated. In treated animals, neither type-I nor type-II endoleaks were observed and a fibro-proliferative response was demonstrated within the aneurysm thrombus.
Conclusions
Host vascular responses govern the fate of the excluded aneurysm. Embolization of the sac and feeding arteries with non-cytotoxic glue sealed all occlusions by stimulating a massive restenosis-like process.
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